Cytotoxic Compounds from Croton cascarilloides

베트남산 Croton cascarilloides의 세포독성 물질

The methanol extract from the root of Croton cascarilloides Raeusch. was primarily evaluated for cytotoxic activity in the cultured human lung cancer cell line (A459) and showed cytotoxic potential with $ED_{50}$ value of $5.98\;{\mu}g/ml$. Bioassayguided fractionation of the root extract resulted in 3-acetyl aleuritolic acid, rubiadin-l-methyl ether, and julocrotine. The structures of the compounds were elucidated from the combination of spectroscopic data and references. In addition, the $^{13}C-NMR$ assignments of rubiadin-l-methyl ether were revised.

베트남산 Croton cascarilloides 뿌리의 메탄올 추출물을 인체 폐암세포인 A549에 대한 세포독성을 실시한 결과 유효함을 발견하였다$(ED_{50},\;5.98\;{\mu}g/ml)$. 세포독성을 측정하면서 유효들 물질을 분리하고 그들의 분광학적 데이터와 문헌치를 비교한 결과 이들은 각각 3-acetyl aleuritolic acid, rubiadin-1-methyl ether 및 julocrotine로 확인되었다.