Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Anti-oxidative Effect of Ginsenoside $Rb_1$ on the HCI.Ethanol-Induced Gastric Tissue in Rats

흰쥐의 염산.에탄올 유발 위염 위조직에서 ginsenoside $Rb_1$의 항산화 효과

  • 현진이 (덕성여자대학교 약학대학) ;
  • 김영식 (서울대학교 천연물과학연구소) ;
  • 정춘식 (덕성여자대학교 약학대학)
  • Published : 2002.09.30
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Abstract

In the previous study, we demonstrated that ginsenoside $Rb_1$ isolated from the butanol fraction of the head of Panax ginseng had significant gastroprotective activity on gastritis and gastric ulcer models in rats. It has been well established that drugs to have capacity of scavenging or inhibiting the generation of reactive oxygen radicals prevent the gastric mucosal injury. Ginsenoside $Rb_1$ was tested on HCl ethanol-induced gastritis in rats, DPPH-induced free radical scavenging effect, MDA assay, GSH activity, and SOD activity in gastric tissue. It showed significant inhibition in HCl ethanol-induced gastritis, and al~o significantly increase of GSH activated SOD. We speculate that the protective effect of ginsenoside $Rb_1$ against HCl ethanol-induced gastric mucosal damage is originated from the increase of GSH and the activation of SOD.

Keywords

References

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