Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Effect of Leweifang on HeLa Cell Vacuolation Induced by Helicobacter.pylori cytotoxin

Helicobacter pylori 독소에 의한 세포의 공포형성에 미치는 생약혼합물의 영향

  • Kwon, Dong-Yeul (Department of Internal Medicine, Shanghai University of Traditional Chinese Medicine) ;
  • Cai, Gan (Department of Internal Medicine, Shanghai University of Traditional Chinese Medicine) ;
  • Shon, Yun-Hee (Department of Pharmacology, College of Medicine and Intractable Disease Research Center, Dongguk University) ;
  • Nam, Kyung-Soo (Department of Pharmacology, College of Medicine and Intractable Disease Research Center, Dongguk University)
  • 권동렬 (상해 중의약대학 중의내과) ;
  • 채감 (상해 중의약대학 중의내과) ;
  • 손윤희 (동국대학교 의과대학 약리학교실 및 난치병한양방치료연구소) ;
  • 남경수 (동국대학교 의과대학 약리학교실 및 난치병한양방치료연구소)
  • Published : 2002.03.30
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Abstract

Helicobacter pylori infection is associated with type B gastritis, peptic ulcer, and gastric cancer. The vacuolation of cells induced by H. pylori is thought to be essential for the initiation and maintenance of gastric infection. The roles of H. pylori cytotoxin, urease, and ammonia in the vacuolation of HeLa cells were determined. Ammonium chloride augmented the neutral red uptake induced by H. pylori toxin. Acetohydroxamic acid (AHA) failed to block the neutral red uptake induced by H. pylori toxin. Leweifang significantly prevented the vacuolation of HeLa cells induced by H. pylori toxin or H. pylori toxin and ammonium chloride. Further investigation is required to determine the mechanisms of Leweifang for the inhibition of vacuole formation of eukaryotic cells in response to the H. pylori toxin.

Keywords

References

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