Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Antioxidant Compounds from Twig of Morus alba

  • Jin, Wen-Yi (College of Pharmacy, Chungnam National University) ;
  • Na, Min-Kyun (College of Pharmacy, Chungnam National University) ;
  • An, Ren-Bo (College of Pharmacy, Chungnam National University) ;
  • Lee, Hyun-Yong (College of Pharmacy, Chungnam National University) ;
  • Bae, Ki-Hwan (College of Pharmacy, Chungnam National University) ;
  • Kang, Sam-Sik (Natural Products Research Institute, Seoul National University)
  • Published : 2002.12.01
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Abstract

The MeOH extract of the twig of Morus alba L. (Moraceae) inhibited strong lipid peroxidation activity. In order to find out active principle from the plant, acivity-guided fractionation was performed and five antioxidant compounds were isolated. Their chemical structures were identified as 6-geranylapigenin (1), 6-geranylnorartocarpetin (2), resveratrol (3), oxyresveratrol (4) and quercetin (5) by physicochemical and spectrometric methods. Compounds 1-5 significantly inhibited lipid peroxidation in rat brain homogenate $(IC_{50}\;values\;of\;3.37,\;3.74,\;0.23,\;0.29\;and\;0.06\; {\mu}M,\;respectively)$.

Keywords

References

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