Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Cytotoxic Activities of Brominated Sesquiterpenes from the Red Alga Laurencia okamurae

  • Ryu, Geon-Seek (Regional Research Center and Department of Chemical Technology, Hanbat National University) ;
  • Park, Soo-Hee (Regional Research Center and Department of Chemical Technology, Hanbat National University) ;
  • Choi, Byoung-Wook (Regional Research Center and Department of Chemical Technology, Hanbat National University) ;
  • Lee, Nam-Ho (Department of Chemistry, Cheju National University) ;
  • Hwang, Hye-Jung (Livechem, INC., Hanbat National University) ;
  • Ryu, Shi-Yong (Korea Research Institute of Chemical Technology) ;
  • Lee, Bong-Ho (Regional Research Center and Department of Chemical Technology, Hanbat National University)
  • Published : 2002.09.01
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Abstract

Four known sesquiterpenes, laurinterol (1), isolaurinterol (2), aplysinal (3) and aplysin (4) were isolated from the Korean red alga Laurencia okamurae off Cheju Island, Korea. Their structures were identified by comparison with the literature data. Compounds 1-4 showed potent cytotoxicity against A549, SK-OV-3, SKMEL-2, XF498, and HTl5 cell lines with $EC_{50}$ values ranging from 1.2 to 17.6 ${\mu}g/ml$.

Keywords

References

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