Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Analgesic, Anti-inflammatory and Diuretic Activities of Pisonia grandis

  • Anbalagan, N. (Department of Pharmaceutical Chemistry, C. L. Baid Metha College of Pharmacy) ;
  • Rajinikanth, K.N. (Department of Pharmaceutical Chemistry and Pharmacology, Vel's College of Pharmacy) ;
  • Gnanasam, S. Kishore (Department of Pharmaceutical Chemistry and Pharmacology, Vel's College of Pharmacy) ;
  • Leonard, J. Thomas (Department of Pharmaceutical Chemistry and Pharmacology, Vel's College of Pharmacy) ;
  • Balakrishna, K. (Department of Phytochemistry, Central Research Institute for Siddha) ;
  • Ramachandran, S. (Department of Pharmaceutical Chemistry, C. L. Baid Metha College of Pharmacy) ;
  • Sridhar, S.K. (Department of Pharmaceutical Chemistry, C. L. Baid Metha College of Pharmacy)
  • Published : 2002.09.01
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Abstract

In the present study, Pisonia grandis leaves were extracted with chloroform and methanol. The extracts were vacuum dried to yield the respective chloroform (CE) and methanol extract (ME). CE and ME were evaluated for analgesic, anti-inflammatory (acute and chronic) and diuretic activity at 2 dose levels (250 and 500 mg/kg). Significant analgesic and anti-inflammatory activities were associated with CE and ME. CE at the dose level of 500 mg/kg was found to exhibit equivalent chronic anti-inflammatory activity as diclofenac at 50 mg/kg dose level. Significant diuretic activity was exhibited by ME. Graded dose response for all the activities were observed for the extracts.

Keywords

References

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