Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Antithrombotic Activity of Sunghyangjunggisan

  • Park, Eun-Kyung (College of Pharmacy, and East-West Research Institute, Kyung Hee University) ;
  • Yoon, Hae-Kyung (Department of Human Life Science, Kyungwon College) ;
  • Kim, Dong-Hyun (College of Pharmacy, and East-West Research Institute, Kyung Hee University,Department of Human Life Science, Kyungwon College)
  • Published : 2002.06.01
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Abstract

As apart of our continuing search for antistroke agents from the herbal medicinal resources, we examined in vitro, ex vivo and in vivo the possibility of Sunghyangjunggisan and its ingradients as a novel antithrombotic agent. In vitro ADP- and collagen-induced rat platelet aggregations were potently inhibited by Arisaematis Rhizoma, Cinnamomi Cortex and Zingiberis Rhizoma in a dose-dependent manner, but not by Sunghyangjunggisan. However, Sunghyangjunggisan significantly inhibited ex vivo rat platelet aggregation. Arisaematis Rhizoma, Atractylodis Rhizoma Alba, and Pinelliae Rhizoma also significantly inhibited ex vivo rat platelet aggregation. Sunghyangjunggisan, Alpiniae Fructus and Zingiberis Rhizoma showed significant protection from death due to pulmonary thrombosis in mice. Therefore, Sunghyangjunggisan can express the antithrombotic action, when it is orally administered.

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References

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