Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Antitumor Activity of Cultured Mycelia of Ganoderma lucidum

  • Min, Byung-Sun (Immunomodulator Laboratory, Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Hyeong-Kyu (Immunomodulator Laboratory, Korea Research Institute of Bioscience and Biotechnology) ;
  • Bae, Ki-Hwan (College of Pharmacy, Chungnam National University) ;
  • Gao, JiangJing (Institute of Natural Medicine, Toyama Medical and Pharmaceutical University) ;
  • Nakamura, Norio (Institute of Natural Medicine, Toyama Medical and Pharmaceutical University) ;
  • Hattori, Masao (Institute of Natural Medicine, Toyama Medical and Pharmaceutical University)
  • Published : 2002.06.01
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Abstract

The cultured mycelia of fungus Ganoderma lucidum were investigated for the inhibitory effect on the growth of s.c. transplanted Lewis lung carcinoma (LLC) in BDF-1 mice by intraperitoneal (i.p.) administration. The cultured mycelia showed antitumor activity with T/C values of 89.6 and 50.3 % at doses of 100 and 500 mg/kg, respectively, compared to adriamycin, which was used a positive control, with T/C value of 54.6 % at 2 mg/kg.

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References

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