The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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Enhanced Expression of Aldosterone Synthase and Adrenome-dullin in Left and Right Ventricular Hypertrophy in Rats

  • Lee, Jong-Un (Department of Physiology and Research Institute of Medical Sciences, Chonnam National University Medical School) ;
  • Lee, Sung-Su (Department of Physiology and Research Institute of Medical Sciences, Chonnam National University Medical School) ;
  • Kim, Sun-Mi (Department of Physiology and Research Institute of Medical Sciences, Chonnam National University Medical School) ;
  • Lee, Won-Jung (Department of Physiology, Kyungpook National University Medical School)
  • Published : 2002.04.21
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Abstract

The pathophysiological implications of aldosterone and adrenomedullin in the cardiac ventricular hypertrophy were examined. Male Sprague-Dawley rats were treated with deoxycorticosterone acetate (DOCA)-salt and monocrotaline (MCT) to selectively elicit left and right ventricular (LV, RV) hypertrophy, respectively. The mRNA expression of aldosterone synthase and adrenomedullin in LV and RV was determined by reverse transcription-polymerase chain reaction. The expression of aldosterone synthase and adrenomedullin was increased in LV, while not altered significantly in RV of DOCA-salt-treated rats. On the contrary, the expression was not significantly altered in LV, but increased in RV of MCT-treated rats. The enhanced expression of aldosterone synthase may be causally related with the development of ventricular hypertrophy, and the increased expression of adrenomedullin may act as a counter-regulatory mechanism.

Keywords

References

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