Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
권호 표지
DOI QR코드

DOI QR Code

Myxochelin A, a cytotoxic antibiotic from the myxobacterium Angiococcus disciformis

  • Ahn Jong-Woong (Medicinal Science Division, Korea Research Institute of Chemical Technology) ;
  • Lee Chong-Ock (Medicinal Science Division, Korea Research Institute of Chemical Technology) ;
  • Baek Seung-Hwa (Department of Herbal Resources, Professional Graduate School of Oriental Medicine, Wonkwang University)
  • Published : 2002.02.01
Download PDF
⟨ Previous Next ⟩

Abstract

In the course of screening for new anticancer antibiotics from myxobacteria, strain JW357 was found to produce an antibiotic that was active against several human cancer cell lines. This strain was identified as Angiacaccus disciformis by morphological and cultural characteristics. The antibiotic produced was identified as myxochelin A. It demonstrated significant cytotoxicity against certain human cancer cells with $IC_{50}$ values ranging 1.15 to $2.36{\mu}g/ml$. Myxochelin A was interestingly as active against multidrug-resistant CL02 cells as against the sensitive parental cells (HCT15).

Keywords

References

  1. Ahn JW, Woo SH, Lee CO, Cho KY, Kim BS. (1999) KR-025, a new cytotoxic compound from M. fulvus. J. Nat. Prod. 62, 495-496.
  2. Cameron JC, Paterson I. (1997) Cancer drugs better than taxol? Nature 387, 238-239. https://doi.org/10.1038/387238a0
  3. Choi SU, Kim NY, Choi EJ, Kim KH, Lee CO. (1996) Establishment of doxorubicin-resistant subline derived from HCT15 human colorectal cancer cells. Arch. Pharm. Res. 19, 342-347. https://doi.org/10.1007/BF02976376
  4. Gerth K, Bedorf N, Hoefle G, Irschik H, Reichenbach H. (1996) Epothilones A and B: Antifungal and cytotoxic compound from S. cellulosum. J. Antibiotics 49, 560-563.
  5. Gerth K, Washausen P, Hoefle G, Irschik H, Reichenbach H. (1996) The jerangolides: a family of new antifungal compound from S. cellulosum. J. Antibiotics 49, 71-75.
  6. Kim YJ, Furihata K, Yamanaka S, Fudo R, Seto H. (1991) Isolation and structural elucidation on stipiamide, a new antibiotic effective to multidrug-resistant cancer cells. J. Antibiotics 44, 553-556.
  7. Kunze B, Bedorf N, Kohl W, Hoefle G, Reichenbach H. (1989) Myxochelin A, a new iron-chelating compound from A. disciformis. J. Antibiotics 42, 14-17.
  8. Reichenbach H, Dworkin M. (1992) The Prokaryotes, 2nd ed., pp3416-3487, Springer Verlag, New York, U.S.A.
  9. Skehan P, Storeng R, Scudiero D, Monks A, McMahon J, Vistica D, Warren J, Bokesch H, Kenny S, Boyd MR. (1990) New colorimetric cytotoxicity assay for anticancer drug screening. J. Nat. Cancer Inst. 82, 1107-1112. https://doi.org/10.1093/jnci/82.13.1107
  10. Takayama S, Yamanaka S, Miyashiro S, Yokokawa Y, Shibai H. (1988) Novel macrocyclic antibiotics: megovalicins A, B, C, D, G and H. J. Antibiotics 41, 439-445.
  11. Trowitzsch-Kienast W, Forche E, Wray V, Reichenbach H, Jurkiewicz E, Hunsmann G, Hoefle G. (1992) Phenalamide, neue HIV-1-inhibitoren aus M. stipitatus Mx s40. Liebigs Ann. Chem. 1992, 659-664. https://doi.org/10.1002/jlac.1992199201112
  12. Wassjohann L. (1997) Epothilones: Promising natural products with taxol-like activity. Angew. Chem. Int. Ed .Engl. 36, 715-718. https://doi.org/10.1002/anie.199707151