The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
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Studies on Inhibitory Effect of Immediate-Type Allergic Reaction of Mahwang-Shin-Gung-San

麻黃辛芎散의 卽時型 알레르기 反應 抑制 效果에 關한 硏究

  • 최정현 (원광대학교 한의과대학 외관과학교실) ;
  • 황충연 (원광대학교 한의과대학 외관과학교실) ;
  • 김남권 (원광대학교 한의과대학 외관과학교실) ;
  • 박민철 (원광대학교 한의과대학 외관과학교실) ;
  • 김진만 (원광대학교 한의과대학 외관과학교실) ;
  • 문상돈 (원광대학교 한의과대학 외관과학교실)
  • Published : 20011200
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Abstract

Mahwang-Shin-Gung-San has been found inhibiting the mast cell-mediated anaphylactic reaction. This report describes an inhibitory effect of Mahwang-Shin-Gung-San (MSGS) on the immediate-type cutaneous allergic reactions. MSGS has concentration -dependently inhibited the ear swelling response induced by compound 48/80 in mouse by intradermal injection. The mast cells in mouse ear tissue undergone ear-swelling response by compound 48/80 were stained by alcian blue/nuclear fast red. MSGS significantly inhibited the compound 48/80-induced degranulation from mast cells in ear tissue. MSGS concentration-dependently inhibited the histamine release from the rat peritoneal mast cells (RPMC) by compound 48/80. We also studied the effect of MSGS on mast cell-dependent passive cutaneous anaphylaxis (PCA) activated by dinitrophenyl IgE antibody. MSGS showed potent inhibition of PCA by oral administration. These results indicate that MSGS inhibits immediate-type allergic reactions by inhibition of mast cell degranulation in vivo and in vitro.

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