The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)
- Volume 14 Issue 2
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- Pages.118-124
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- 2001
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- 1738-6640(pISSN)
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- 2234-4020(eISSN)
Single dose toxicity study of Injinhotang in rat
茵蔯蒿湯의 랫드에서의 單回投與毒性試驗
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Kim, S.C.
(College of oriental medicine, Jeahan oriental medicial academy, Kyungsan University) ;
- Byun, J.S. (College of oriental medicine, Jeahan oriental medicial academy, Kyungsan University) ;
- Park, J.H. (College of oriental medicine, Jeahan oriental medicial academy, Kyungsan University) ;
- Jee, S.Y (College of oriental medicine, Jeahan oriental medicial academy, Kyungsan University) ;
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Byun, S.H.
(College of oriental medicine, Jeahan oriental medicial academy, Kyungsan University) ;
- Lee, H.S. (College of oriental medicine, Faculty of Natural science, Kyungsan University)
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김상찬
(경산대학교 한의과대학 제한동의학술원) ;
- 변준철 (경산대학교 한의과대학 제한동의학술원) ;
- 박종현 (경산대학교 한의과대학 제한동의학술원) ;
- 지선영 (경산대학교 한의과대학 제한동의학술원) ;
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변성희
(경산대학교 한의과대학 제한동의학술원) ;
- 이형식 (경산대학교 한의과대학 자연과학부)
- Published : 20011200
Abstract
The single dose toxicity of Injinhotang, a herbal drug for treatment of hepatic injuries. was evaluated in Sprague-Dawley rats. Injinhotang was once administered to both sexes of rats at the dose levels of 2000, 1000, 500, 250 and 125 mg/kg for oral route. After single administration, clinical signs were observed every day for 14 days and body weights were measured 5 times including initial measurement on day 0 (the days of administration). When observation period was over, the animals were sacrificed and macroscopic examination of major organs was conducted. In addition, the histopathological profiles of these major organs were also conducted. Neither significant clinical signs nor death after administration was observed during the observation periods except for soft feces or diarrhea. In addition, no abnormal necropsy findings, changes of body weight and histopathological profiles were observed at terminal necropsy in both sexes. From these results, it is considered that