Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Relationship of Estrogen to Extrapyramidal Symptoms in Female Schizophrenic Patients

여자 정신분열병 환자에서 혈중 에스트로겐 농도와 추체외로 증상과의 관계

  • Chung, Dong Seon (Chun-an Medical Center) ;
  • Jung, Hee Yeon (Department of Psychiatry, College of Medicine, Soonchunhyang University) ;
  • Kwon, Young Joon (Department of Psychiatry, College of Medicine, Soonchunhyang University) ;
  • Park, In Joon (Department of Psychiatry, College of Medicine, Soonchunhyang University) ;
  • Han, Sun Ho (Department of Psychiatry, College of Medicine, Soonchunhyang University) ;
  • Jung, Han Yong (Department of Psychiatry, College of Medicine, Soonchunhyang University)
  • 정동선 (천안의료원) ;
  • 정희연 (순천향대학 천안병원 신경정신과학교실) ;
  • 권영준 (순천향대학 천안병원 신경정신과학교실) ;
  • 박인준 (순천향대학 천안병원 신경정신과학교실) ;
  • 한선호 (순천향대학 서울병원 신경정신과학교실) ;
  • 정한용 (순천향대학 부천병원 신경정신과학교실)
  • Published : 2001.06.30
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Abstract

Objective : It has been thought that estrogen has neuroleptic like effect in women schizophrenic patients. This study aimed to investigate neuroleptic side-effects severity in women with schizophrenia and to investigate their putative association with variations in sex steroids over menstrual cycle. Based on the estrogen theory, The author hypothesized that parkinsonian side-effects would be exacerbated when estrogen levels were high. Method : 26 schizophrenic women were assessed using the ESRS(Extrapyramidal Symptom Rating Scale) and estrogen analysis. Tests were conducted twice, in the mid luteal and mid follicular phase. Result : It was hypothesized that high level of estrogen would lead to an exacerbation of parkinsonian side-effects but the results indicated that parkinsonian side effects decreased overall when estrogen levels were high. This effects were more marked for the group taking typical neuroleptics than those taking atypical neuroleptics. Conclusion : The results of this study suggest that estrogen and progesteron may reduce the severity of neuroleptic induced extrapyramidal side effects over menstrual cycle in women with schizophrenia. It was concluded that estrogen has different effects on dopamine dynamics in the mesolimbic and mesostriatal pathways according to estrogen, progesteron, catecol estrogen, prolactine.

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