Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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Effect of Pretreatment of (-)-3-PPP on the Haloperidol-Induced Extracellular Dopamine Concentrations in the Nucleus Accumbens of Rats

백서(白鼠) 중격측좌핵에서 Haloperidol로 유발된 세포외 도파민 농도 변화에 대한 (-)-3-PPP 전처치 효과

  • Chung, Young-Chul (Department of Psychiatry, Institute for Medical Science and Research Institute of Clinical Medicine, Chonbuk National University, Medical School) ;
  • Eun, Hong-Bae (Department of Psychiatry, Institute for Medical Science and Research Institute of Clinical Medicine, Chonbuk National University, Medical School) ;
  • Hwang, Ik-Keun (Department of Psychiatry, Institute for Medical Science and Research Institute of Clinical Medicine, Chonbuk National University, Medical School) ;
  • Park, Tae-Won (Department of Psychiatry,Chonbuk National University Hospital)
  • Published : 2001.06.30
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Abstract

Objectives : To investigate the effects of (-)-3-PPP(0.5, 2, and 10mg/kg, s.c.) and haloperidol(0.1, 0.5, and 2mg/kg, s.c.) on the extracellular dopamine concentrations, and the effect of pretreatment with (-)-3-PPP(2mg/kg) on the haloperidol(2mg/kg)-induced extracellular dopamine concentrations in the nucleus accumbens(NAS) of free moving rats. Methods : Dopamine levels in dialysate were determined with high pressure liquid chromatography(HPLC) with electrochemical detection(ECD). Results : (1)(-)-3-PPP had dual actions depending on the doses: at 2mg/kg, it decreased and at 10mg/kg, increased extracellular dopamine concentrations ; (2) haloperidol at all doses increased dopamine levels with higher dose having a greater increase; and (3) pretreatment of (-)-3-PPP reduced the increase in dopamine levels elicited by acute treatment with haloperidol. Conclusions : These findings suggest that pretreatment of (-)-3-PPP in low dose could accelerate the onset of therapeutic effect of haloperidol by diminishing the haloperidol-induced dopamine release in the limbic system.

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