BMB Reports
- 제34권5호
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- Pages.484-488
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- 2001
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- 1976-670X(eISSN)
Role of STAT3 as a Molecular Adaptor in Cell Growth Signaling: Interaction with Ras and other STAT Proteins
- Song, Ji-Hyon (Department of Biological Science and Institute for Basic Science, SungKyunKwan University) ;
- Park, Hyon-Hee (Department of Biological Science and Institute for Basic Science, SungKyunKwan University) ;
- Park, Hee-Jeong (Department of Biological Science and Institute for Basic Science, SungKyunKwan University) ;
- Han, Mi-Young (Institute of Medical Genetics, Green Cross Reference Lab.) ;
- Kim, Sung-Hoon (Department of Biological Science and Institute for Basic Science, SungKyunKwan University) ;
- Lee, Choong-Eun (Department of Biological Science and Institute for Basic Science, SungKyunKwan University)
- 투고 : 2001.08.27
- 심사 : 2001.08.29
- 발행 : 2001.09.30
초록
STATs are proteins with a dual function: signal transducers in the cytoplasm and transcriptional activators in the nucleus. Among the six known major STATs (STAT1-6), STAT3 has been implicated in the widest range of signaling pathways that regulate cell growth and differentiation. As a part of our on-going investigation on the pleiotropic functions of STAT proteins, we examined the role of STAT3 as a molecular adaptor that links diverse cell growth signaling pathways. We observed that STAT3 can be specifically activated by multiple cytokines, such as IL-3, in transformed fibroblasts and IL-4 or IFN-
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