Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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A Case of Nonspecific Interstitial Pneumonia Associated with Systemic Lupus Erythematosus

전신성 홍반성 낭창에 병발된 비특이성 간질성 폐렴 1예

  • Lee, Ho-Moeng (Department of Internal Medicine, Gachon Medical School, Ghil Medical Center) ;
  • Hwang, Jae-Kyung (Department of Internal Medicine, Gachon Medical School, Ghil Medical Center) ;
  • Park, Gae-Young (Department of Internal Medicine, Gachon Medical School, Ghil Medical Center) ;
  • Park, Jeong-Woong (Department of Internal Medicine, Gachon Medical School, Ghil Medical Center) ;
  • Park, Jae-Kyung (Department of Internal Medicine, Gachon Medical School, Ghil Medical Center) ;
  • Jeong, Seong-Hwan (Department of Internal Medicine, Gachon Medical School, Ghil Medical Center) ;
  • Nam, Gui-Hyun (Department of Internal Medicine, Gachon Medical School, Ghil Medical Center) ;
  • Lee, Jae-Woong (Department of Thoracic surgery, Gachon Medical School, Ghil Medical Center) ;
  • Ha, Seung-Yeon (Department of Pathology, Gachon Medical School, Ghil Medical Center) ;
  • Lee, Han-Kyung (Department of Radiology, Gachon Medical School, Ghil Medical Center)
  • 이호명 (가천의대부속 길병원 호흡기내과) ;
  • 황재경 (가천의대부속 길병원 호흡기내과) ;
  • 박계영 (가천의대부속 길병원 호흡기내과) ;
  • 박정웅 (가천의대부속 길병원 호흡기내과) ;
  • 박재경 (가천의대부속 길병원 호흡기내과) ;
  • 정성환 (가천의대부속 길병원 호흡기내과) ;
  • 남귀현 (가천의대부속 길병원 호흡기내과) ;
  • 이재웅 (가천의대부속 길병원 흉부외과) ;
  • 하승연 (가천의대부속 길병원 해부병리과) ;
  • 이한경 (가천의대부속 길병원 진단방사선과)
  • Published : 2001.06.30
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Abstract

Systemic lupus erythematosus frequently has thoracic involvement among connective tissue diseases. One of the pleuropulmonary manifestations is diffuse interstitial lung disease including nonspecific interstitial pneumonia(NSIP). NSIP is a newly classified disease among interstitial lung diseases. Systemic lupus erythematosus has a better prognosis than usual interstitial peumonia(UIP) and responds well to steroids. In this report, a 34 year-old woman who complained of a dry cough, and exertional dyspnea for 2 months is described. The chest X-ray showed fine reticular opacities and a mild honeycomb appearance in both basal lungs. High resolution computed tomography(HRCT) showed bilateral patchy areas of ground-glass attenuation and a mild honeycomb appearance in the subpleural of both the lower and the middle portion of the lung fields. An open lung biopsy showed prominent lymphocytic interstitial inflammation and fibrosis with small areas with a honeycomb appearance. This case was diagnosed as NSIP associated with systemic lupus erythematosus and was managed with oral steroids. Here we report a case of nonspecific interstitial pneumonia associated with systemic lupus erythematosus confirmed by HRCT and an open lung biopsy with a review of the relevant literature.

교원성 질환에 병발하여 나타나는 간질성 폐렴은 여러가지가있으며, 이 중 비특이성 간질성 폐렴은 통상성 간질성 폐렴과는 달리, 예후가 좋고 스테로이드에 반응이 좋은 질병이다. 저자들은 전신성 홍반성 낭창에 동반된 비특이성 간질성 폐렴환자를 경험하고, 스테로이드를 써서 치료 후 외래에서 추적 관찰하는 1예가 있었기에 문헌 고찰과 함께 보고하는 바이다.

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