Tuberculosis and Respiratory Diseases
- 제50권6호
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- Pages.676-685
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- 2001
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- 1738-3536(pISSN)
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- 2005-6184(eISSN)
비소세포폐암의 예후인자로서 Vascular Endothelial Growth Factor(VEGF)의 의의
Prognostic Value of Vascular Endothelial Growth Factor (VEGF) in Resected Non-Small Cell Lung Cancer
- 고혁재 (원광대학교 의과대학 내과학교실) ;
- 박정현 (원광대학교 의과대학 내과학교실) ;
- 심혁 (원광대학교 의과대학 내과학교실) ;
- 양세훈 (원광대학교 의과대학 내과학교실) ;
- 정은택 (원광대학교 의과대학 내과학교실)
- Ko, Hyeck-Jae (Department of Internal Medicine, College of Medicine, Wonkwang University) ;
- Park, Jeong-Hyun (Department of Internal Medicine, College of Medicine, Wonkwang University) ;
- Shim, Hyeok (Department of Internal Medicine, College of Medicine, Wonkwang University) ;
- Yang, Sei-Hoon (Department of Internal Medicine, College of Medicine, Wonkwang University) ;
- Jeong, Eun-Taik (Department of Internal Medicine, College of Medicine, Wonkwang University)
- 발행 : 2001.06.30
초록
연구배경 : 종양 내 혈관신생은 고형성 종양의 성장이나 전이에 매우 중요한 인자로 종양의 부피가
Background : Angiogenesis is an essential component of tumor growth and metastasis, and the vascular endothelial growth factor (VEGF) is one of the most important angiogenic factors. Several solid tumors produce substantial amounts of VEGF, which stimulates proliferation and the migration of endothelial cells, thereby inducing neovasculization by a paracrine mechanism. To evaluate the prognostic roles of angiogenesis and VEGF expression in patients with non-small cell lung cancer, the relationship between VEGF expression in tumor tissues, the clinicopathologic features and the overall survival rate were analysed. Methods : Sixty-nine resected primary non-small cell lung cancer specimens were evaluated. The paraffin-embedded tumor tissues were stained by anti-VEGF polyclonal antibodies using an immunohistochemical method to assess VEGF expression. Results : In Forty-one patients (59%), the VEGF antigen was expressed weakly in their tumor tissue, whereas in twenty-eight patients (41%) the VEGF antigen was expressed strongly. The median survival time of the weak VEGF expression group was 24 months, and that of the strong VEGF expression group was 19 months. The three year-survival rates were 35%, 33%, respectively. The survival difference between both groups was not statistically significant. Conclusion : Although results were not statistically significant, the strong expression group tended to poorer prognosis than the weak expression group.