Tuberculosis and Respiratory Diseases
- 제50권4호
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- Pages.437-449
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- 2001
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- 1738-3536(pISSN)
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- 2005-6184(eISSN)
중증 지역사회획득 폐렴환자의 예후에 영향을 미치는 면역지표에 대한 연구
Prospective Study of the Immunologic Factors Affecting the Prognosis of Severe Community-Acquired Pneumonia
- 황재경 (가천의과대학교 길병원 호흡기내과) ;
- 이호명 (가천의과대학교 길병원 호흡기내과) ;
- 송광식 (가천의과대학교 길병원 호흡기내과) ;
- 박계영 (가천의과대학교 길병원 호흡기내과) ;
- 박정웅 (가천의과대학교 길병원 호흡기내과) ;
- 박재경 (가천의과대학교 길병원 호흡기내과) ;
- 정성환 (가천의과대학교 길병원 호흡기내과) ;
- 안정열 (가천의과대학교 길병원 임상병리과) ;
- 서일혜 (가천의과대학교 길병원 임상병리과) ;
- 남귀현 (가천의과대학교 길병원 호흡기내과)
- Hwang, Jae-Kyung (Department of Internal Medicine, Gachon Medical School, Gil Medical Center) ;
- Lee, Ho-Moeng (Department of Internal Medicine, Gachon Medical School, Gil Medical Center) ;
- Song, Kwang-Sik (Department of Internal Medicine, Gachon Medical School, Gil Medical Center) ;
- Park, Gye-Young (Department of Internal Medicine, Gachon Medical School, Gil Medical Center) ;
- Park, Jeong-Woong (Department of Internal Medicine, Gachon Medical School, Gil Medical Center) ;
- Park, Jae-Kyung (Department of Internal Medicine, Gachon Medical School, Gil Medical Center) ;
- Jeong, Seong-Hwan (Department of Internal Medicine, Gachon Medical School, Gil Medical Center) ;
- Ahn, Jeong-Yeal (Department of Clinical Pathology, Gachon Medical School, Gil Medical Center) ;
- Seo, Yiel-Hea (Department of Clinical Pathology, Gachon Medical School, Gil Medical Center) ;
- Nam, Gui-Hyun (Department of Internal Medicine, Gachon Medical School, Gil Medical Center)
- 발행 : 2001.04.30
초록
연구배경 : 중증 지역사회획득 폐렴환자에서 어떤 면역학적 요인이 중요한 예후 인자로 작용하는지와 그에 대한 예방과 개선방법을 알아보기 위해 연구를 시행하였다. 방 법 : 중증 폐렴환자 23명을 임상경과에 따라 회복군(n=16)과 사망군(n=7) 으로 나눈 후, 말초혈액에서 전혈구검사, 혈청 생화학검사, 면역글로블린, 보체, 림프구 아세포군 검사, 객담 및 혈액배양검사, 소변검사, 흉부 x-선 검사등을 시행하였다. 결 과 : 1) 양 군에서 말초혈액검사상 림프구감소증 소견이 있었다(림프구 평균 회복군
Background : In the severe community-acquired pneumonia, it has been known that the immune status is occasionally suppressed. This study was performed to identify the immunologic markers related with the prognostic factors in severe community-acquired pneumonia. Methods : 23 patients with severe community-acquired pneumonia were involved in this study, and divided into survivor (16) and nonsurvivor (7) groups. In this study, the medical history, laboratory tests(complete blood counts, routine chemistry profile, immunoglobulins, complements, lymphocyte subsets, cytokines, sputum and blood culture, urine analysis), and chest radiographs were scrutinized. Results : 1) Both groups had lymphopenia(total lymphocyte count