IMMUNE NETWORK
- 제1권1호
- /
- Pages.36-44
- /
- 2001
- /
- 1598-2629(pISSN)
- /
- 2092-6685(eISSN)
위암세포에서 세포유착물질의 발현 및 위암세포의 복막 내피세포에 대한 결합 능에 미치는 retinoicacid의 영향
The effect of retinoic acid on the expression of cell adhesion molecules and binding ability to peritoneal mesothelium in gastric cancer cells
- 홍영선 (가톨릭대학교 의과대학 내과학교실) ;
- 박조현 (가톨릭대학교 의과대학 외과학교실) ;
- 박진노 (가톨릭대학교 의과대학 내과학교실) ;
- 이경식 (가톨릭대학교 의과대학 내과학교실) ;
- 김인철 (가톨릭대학교 의과대학 외과학교실)
- Hong, Young Seon (Department of Internal Medicine, Catholic University Medical College of Korea) ;
- Park, Cho Hyun (Department of Surgery, Catholic University Medical College of Korea) ;
- Park, Jin-No (Department of Internal Medicine, Catholic University Medical College of Korea) ;
- Lee, Kyung Shik (Department of Internal Medicine, Catholic University Medical College of Korea) ;
- Kim, In Chul (Department of Surgery, Catholic University Medical College of Korea)
- 발행 : 2001.04.30
초록
Background : Peritoneal metastasis is one of the maj or types of the stomach cancer recurrence and the role of the adhesion molecules is thought to be very much important in this event. Retinoic acid (RA) has been known to induce the growth inhibition and differentiation of various malignancies, and apoptpsis and the change of expression of adhesion molecules have been reported to be involved in the action of RA. Methods : We studied the adhesion abilities of SNU-1, SNU-5, and SNU-6 cells to the peritoneal endothelial cells as well as the expression of the adhesion molecules (CD44, ICAM-1) in Western blot analysis. And also we studied the expression of apoptosis and the change of expression patterns of the various isoforms of CD44 and the change of the adhsion abilities of the cell line cells after RA treatment. Results: CD44 was expressed in SNU-5 and -16, together with an isoform in SNU-16. ICAM-1 was not expressed in any of the cell line cells tested. After the treatment of RA in the concentration range of