Journal of Korean Neurosurgical Society
- Volume 30 Issue 7
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- Pages.855-860
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- 2001
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- 2005-3711(pISSN)
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- 1598-7876(eISSN)
Malignant Transformation of Hemispheric Low-Grade Gliomas : Clinical Analysis and Prognostic Factors
뇌반구에 위치한 양성신경교종의 악성전환에 대한 임상적 연구
- Cho, Keun-Tae (Department of Neurosurgery, Seoul National University, College of Medicine) ;
- Gwak, Ho-Shin (Department of Neurosurgery, Seoul National University, College of Medicine) ;
- Jung, Hee-Won (Department of Neurosurgery, Seoul National University, College of Medicine) ;
- Paek, Sun-Ha (Department of Neurosurgery, Seoul National University, College of Medicine) ;
- Chung, Young Seob (Department of Neurosurgery, Seoul National University, College of Medicine) ;
- Kim, Dong Gyu (Department of Neurosurgery, Seoul National University, College of Medicine) ;
- Cho, Byung Kyu (Department of Neurosurgery, Seoul National University, College of Medicine)
- 조근태 (서울대학교 의과대학 신경외과학교실) ;
- 곽호신 (서울대학교 의과대학 신경외과학교실) ;
- 정희원 (서울대학교 의과대학 신경외과학교실) ;
- 백선하 (서울대학교 의과대학 신경외과학교실) ;
- 정영섭 (서울대학교 의과대학 신경외과학교실) ;
- 김동규 (서울대학교 의과대학 신경외과학교실) ;
- 조병규 (서울대학교 의과대학 신경외과학교실)
- Received : 2000.03.09
- Accepted : 2001.06.25
- Published : 2001.07.28
Abstract
Introduction : It has been reported that the survival of low-grade glioma patients depends upon the time of malignant transformation. The authors presents the clinical analysis of histologically proven trasformed gliomas. Materials and Method : A total 92 patients who were consecutively treated and histologically confirmed hemispheric low-grade gliomas between 1980 and 1998 were analyzed and followed. All cases meet the criteria of WHO glioma classification of grade II. Results : The mean follow-up period was 73 months. Twenty two among 92 cases(24%) were histologically proven to be transformed into malignant ones. The mean time to transformation was 56 months. The 5-year and 10-year survival rates of the transformed group were 66% and 30% respectively and significantly different from the survival rates of the non-transformed group(p=0.0018). Among clinical factors at presentation, the initial tumor volume had a tendency to be larger in the transformed group than that of the non-transformed group and became significant when it was divided into more than