Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
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The Effect of Albumin Therapy for Reperfusion Injury Following Transient Focal Cerebral Ischemia in Rats

쥐에서 일과성 국소 뇌허혈 후 생긴 재관류 손상시 알부민치료의 효과

  • Huh, Pil Woo (Department of Neurosurgery, Uijongbu St. Mary's Hospital, The Catholic University of Korea, College of Medicine) ;
  • Cho, Kyoung Suck (Department of Neurosurgery, Uijongbu St. Mary's Hospital, The Catholic University of Korea, College of Medicine) ;
  • Yoo, Do Sung (Department of Neurosurgery, Uijongbu St. Mary's Hospital, The Catholic University of Korea, College of Medicine) ;
  • Kim, Jae Keon (Department of Neurosurgery, Uijongbu St. Mary's Hospital, The Catholic University of Korea, College of Medicine) ;
  • Kim, Dal Soo (Department of Neurosurgery, Uijongbu St. Mary's Hospital, The Catholic University of Korea, College of Medicine) ;
  • Kang, Joon Ki (Department of Neurosurgery, Uijongbu St. Mary's Hospital, The Catholic University of Korea, College of Medicine)
  • 허필우 (가톨릭대학교 의과대학 의정부성모병원 신경외과학교실) ;
  • 조경석 (가톨릭대학교 의과대학 의정부성모병원 신경외과학교실) ;
  • 유도성 (가톨릭대학교 의과대학 의정부성모병원 신경외과학교실) ;
  • 김재건 (가톨릭대학교 의과대학 의정부성모병원 신경외과학교실) ;
  • 김달수 (가톨릭대학교 의과대학 의정부성모병원 신경외과학교실) ;
  • 강준기 (가톨릭대학교 의과대학 의정부성모병원 신경외과학교실)
  • Received : 2000.02.11
  • Accepted : 2000.08.03
  • Published : 2001.01.28
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Abstract

Objective : Albumin is a very useful drug for the improving of cerebral blood volume and the oncotic effect in cerebral ischemia or cerebral vasospasm. The purpose of this study was to examine the morphological and neurological effect of albumin therapy on reperfusion injury following transient focal cerebral ischemia. Materials and Methods : 18 Male Sprague-Dawley rats weighing 270-320g were used. The ischemia model was produced by 2-hour period of transient middle cerebral artery occlusion with a poly-L-lysin coated intraluminal suture. The agent(20% human serum albumin[HSA]) or control solution(NaCl 0.9%) was administered intravenously at a dosage of 1% of body weight immediate after reperfusion following a 2-hour period occlusion. Neurological function was evaluated by the postural reflex and the forlimb placing test during occlusion(at 60 min) and daily for 3 days thereafter. The brain was perfusion-fixed, and infarct volumes and brain edema were measured. Results : The HSA significantly improved the neurological score in treated group. The rats of albumin treatment group showed significantly reduced total infarct volume(by 34%) and brain edema(by 81%) compared with salinetreated rats. Conclusion : HSA showed a substantial effect on the transient focal cerebral ischemia and reperfusion injury model. These results may indicate its usefulness in treating reperfusion injury patients after thrombolysis treatment for the thrombo-embolic major cerebral artery occlusions.

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