Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
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The Role of Basic Fibroblast Growth Factor in Moyamoya Disease

모야모야병에서 염기성 섬모 세포 성장 인자의 역할

  • Kim, Dong-Seok (Department of Neurosurgery, Brain Research Institute Yonsei University College of Medicine) ;
  • Choi, Joong-Uhn (Department of Neurosurgery, Brain Research Institute Yonsei University College of Medicine) ;
  • Kim, Se-Hyuk (Department of Neurosurgery, Brain Research Institute Yonsei University College of Medicine) ;
  • Yang, Kook-Hee (Department of Neurosurgery, Brain Research Institute Yonsei University College of Medicine) ;
  • Kim, Hyeun-Sook (Department of Clinical Pathology, Brain Research Institute Yonsei University College of Medicine)
  • 김동석 (연세대학교 의과대학 신경외과학교실) ;
  • 최중언 (연세대학교 의과대학 신경외과학교실) ;
  • 김세혁 (연세대학교 의과대학 신경외과학교실) ;
  • 양국희 (연세대학교 의과대학 신경외과학교실) ;
  • 김현숙 (연세대학교 의과대학 임상병리학교실)
  • Received : 1999.12.03
  • Accepted : 2000.08.16
  • Published : 2001.01.28
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Abstract

Objectives and Importance : The present study investigated the levels of basic fibroblast growth factor(bFGF) in the CSF of patients with moyamoya disease and its clinical significance. Methods : The levels of bFGF in CSF, taken from 26 hemispheres of 14 moyamoya patients and 20 patients without vascular anomaly(control group), were measured by an enzyme-linked immunosorbent assay. We analyzed the correlation between the level of bFGF and the clinical factors such as age, onset pattern, development of neovascularization, and cerebral circulation. Results : The CSF of moyamoya patients contained a high concentration of bFGF to a significant extent. The bFGF level was apparently elevated in the patients in whom neovascularization from indirect revascularization, such as modified encephalo-duro-arterio-synangiosis(EDAS) was well developed. A linear correlation between the values of bFGF and clinical progression was noted. Conclusions : The elevation of bFGF in moyamoya disease seems to be specific. Clinically, the bFGF level may be considered a useful indicator to predict the efficacy of indirect revascularization.

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