Annals of Clinical Neurophysiology

The Korean Society of Clinical Neurophysiology (대한임상신경생리학회)
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Clinical study of Myasthenia Gravis associated with other autoimmune diseases

자가면역질환과 동반된 중증근무력증의 임상적 연구

  • Kim, Byung Jo (Department of Neurology, College of Medicine, Korea University) ;
  • Koh, Seong Beom (Department of Neurology, College of Medicine, Korea University) ;
  • Park, Min Kyu (Department of Neurology, College of Medicine, Korea University) ;
  • Park, Kun Woo (Department of Neurology, College of Medicine, Korea University) ;
  • Lee, Dae Hie (Department of Neurology, College of Medicine, Korea University)
  • 김병조 (고려대학교 의과대학 신경과학교실) ;
  • 고성범 (고려대학교 의과대학 신경과학교실) ;
  • 박민규 (고려대학교 의과대학 신경과학교실) ;
  • 박건우 (고려대학교 의과대학 신경과학교실) ;
  • 이대희 (고려대학교 의과대학 신경과학교실)
  • Published : 2001.07.30
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Abstract

Background & Object : Myasthenia gravis(MG) is an autoimmune disease due to binding of antibody to acetylcholine receptors on the muscle membrane. It is well known that other autoimmune diseases infrequently accompany myasthenia gravis. The aim of this study was to evaluate the clinical significance of associated autoimmune diseases(AAD) and compare prognosis between MG with AAD and MG without AAD. Method : A total of 65 MG patients(24 men and 41 women) were enrolled at this study. From the clinical records of these patients, we investigated the clinical characteristics and prognosis of MG with AAD and compared these data with those of MG without other such diseases. Results : AAD were found in 10 of 65 cases(15%). 9 cases of 10 MG with AAD were generalized MG type. The most common disease was thyroid disorder. The rate of AAD was higher in thymic abnormal patients. There was no significant remission rate difference between MG with AAD and MG without AAD, but the percentage of patients experienced crisis was higher in MG with AAD. Conclusion : The occurrence of AAD may suggest a more generalized autoimmune disturbance that could be associated with a less favorable prognosis.

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