Fisheries and Aquatic Sciences
- Volume 4 Issue 4
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- Pages.197-200
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- 2001
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- 2234-1757(eISSN)
Correlation between Pharmacokinetics of Praziquantel and Extermination of Microcotyle sebastis (Monogenea) in Cultured Rockfish Sebastes schlegeli
- Kim Chun Soo (Department of Aquatic Life Medicine, Pukyong National University) ;
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Kim Ki Hong
(Department of Aquatic Life Medicine, Pukyong National University)
- Published : 2001.12.01
Abstract
To investigate the re-treatment time of Microcotyle sebastis by oral administration of praziquantel, the residue levels of praziquantel in plasma of rockfish Sebastes schlegeli administered orally at a dose of 200 mg/kg B.W. were analyzed by reversed-phase HPLC, and the concentrations of praziquantel in the plasma were correlated with the extermination of M. sebastis. The absorption and depletion of praziquantel in the blood of rockfish were fast and the residual concentrations of praziquantel declined below