Korean Journal of Veterinary Research (대한수의학회지)
- Volume 41 Issue 3
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- Pages.327-332
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- 2001
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- 2466-1384(pISSN)
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- 2466-1392(eISSN)
Effects of melatonin on heart rate and blood pressure in rat I. Effects on blood pressure
멜라토닌이 랫트에서 심박수 및 혈압에 미치는 효과 I. 혈압에 미치는 효과
- Oh, Sung-suck (Bio-Safety Research Institute, Chonbuk National University) ;
- Kim, Shang-jin (Bio-Safety Research Institute, Chonbuk National University) ;
- Kim, Jin-shang (Bio-Safety Research Institute, Chonbuk National University)
- Accepted : 2001.08.17
- Published : 2001.09.25
Abstract
In recent years, experimental evidence have been suggested that melatonin has either contractive or relaxing effects on the vascular smooth muscle in vitro. But the effect of melatonin on the cardiovascular system in vivo had been emphasized about the hypotensive effect. In this work, we found not only hypotensive effect but also hypertensive effect of melatonin in rats and attempted to determine the mechanism of these effects elicited by melatonin. Regadless of concentration, melatonin(0.002~5 mg/kg) produced increase in mean blood pressure (MBP) in 36% (54/150 cases) and decrease in mean blood pressure in 64%(96/150 cases). As a whole melatonin caused an increase or a decrease in MBP without compensatory decrease or increase in heart rate. The melatonin-induced hypertension was abolished by the pretreatment of phenoxybenzamine, a