DOI QR코드

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Current Status of Quantitative Trait Locus Mapping in Livestock Species - Review -

  • Kim, Jong-Joo (Dept. of Genetics, Faculty of Veterinary Medicine, University of Liege) ;
  • Park, Young I. (School of Agricultural Biotechnology, Seoul National University)
  • 발행 : 2001.04.01

초록

In the last decade, rapid developments in molecular biotechnology and of genomic tools have enabled the creation of dense linkage maps across whole genomes of human, plant and animals. Successful development and implementation of interval mapping methodologies have allowed detection of the quantitative trait loci (QTL) responsible for economically important traits in experimental and commercial livestock populations. The candidate gene approach can be used in any general population with the availability of a large resource of candidate genes from the human or rodent genomes using comparative maps, and the validated candidate genes can be directly applied to commercial breeds. For the QTL detected from primary genome scans, two incipient fine mapping approaches are applied by generating new recombinants over several generations or utilizing historical recombinants with identity-by-descent (IBD) and linkage disequilibrium (LD) mapping. The high resolution definition of QTL position from fine mapping will allow the more efficient implementation of breeding programs such as marker-assisted selection (MAS) or marker-assisted introgression (MAI), and will provide a route toward cloning the QTL.

키워드

피인용 문헌

  1. Multiple Quantitative Trait Locus Analysis of Bovine Chromosome 6 in the Israeli Holstein Population by a Daughter Design vol.159, pp.2, 2001, https://doi.org/10.1093/genetics/159.2.727
  2. Evaluation of a New Fine-mapping Method Exploiting Linkage Disequilibrium: a Case Study Analysing a QTL with Major Effect on Milk Composition on Bovine Chromosome 14 vol.15, pp.9, 2002, https://doi.org/10.5713/ajas.2002.1250
  3. Detection of Quantitative Trait Loci for Growth and Carcass Traits on BTA6 in a Hanwoo Population vol.23, pp.3, 2001, https://doi.org/10.5713/ajas.2010.90586
  4. Polymorphism of Genes of the Protein and Lipid Exchanges in Modern Ukranian Breeds of Cattle Bred for Dairy Productivity vol.74, pp.6, 2001, https://doi.org/10.2478/prolas-2020-0056