한국응용과학기술학회지 (Journal of the Korean Applied Science and Technology)
- 제18권3호
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- Pages.180-185
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- 2001
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- 1225-9098(pISSN)
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- 2288-1069(eISSN)
DOI QR Code
Sulfamethazine에 의한 폴리아크릴산의 항균 효과
Antibiotics Effect of Synthetic Polyacrylic Acid Containing Sulfamethazine
- 윤철훈 (명지대학교 공과대학 화학공학과)
- Yoon, Cheol-Hun (Dept. of chemical Engineering, Myongji University)
- 발행 : 2001.09.30
초록
Antibiotics polymer prepared by chemical bonding and simple blending of antibacterial into polymers have attracted much interest because of their long-lasting and antibacterial activity. Antibiotics polymer can significantly reduce losses associated with dissolution, photolytic decomposition and volatillization. Further more, increased efficiency safety and selectivity are additional benefits which may be realized. In this study, Antibiotics polymer was synthesized by chemical reaction of polyacrylic acid with sulfamethazine by N,N'-dicyclohexylcarbodiimide(DCC) method. Antibacterial susceptibility was determined against Streptococcus pyrogenes[gram(+)] and Esherichia coli.[gram(-)] using a standardized disc test. As a result, the synthetic antibiotics polymer exhibited the broad susceptibilty against Streptococcus pyrogenes and Esherichia coli. Especially, the antibiotic effect of antibacterial polymer against Gram negative(Esherichia coli) was much stronger than that against Gram positive(Streptococcus pyrogenes).