Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Leukotriene D4 Antagonistic Activity of a Stilbene Derivative Isolated from the Bark of Pinus Koraiensis

  • Song, Hong Keun (Department of Forest Resources, Konkuk University) ;
  • Jung, Jihyun (Department of Applied Biology & Chemistry, Konkuk University) ;
  • Park, Kwan Ha (Department of Marine Biomedical Sciences, Kunsan National University) ;
  • Lim, Yoongho (Department of Applied Biology & Chemistry, Konkuk University)
  • Received : 2001.10.12
  • Published : 2001.12.31
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Abstract

A phenolic substance was isolated from the bark of Pinus koraiensis. It was identified to be pinostilbenoside. Its anti-$LTD_4$ activity was evaluated using isolated guinea pig trachea, and its half maximal bronchodilating activity ($EC_{50}$) was $593{\pm}56{\mu}g{\cdot}ml^{-1}$. Because it is not known that stilbene derivatives possess anti-asthmatic activity through $LTD_4$ antagonism, here we report the result.

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