Pediatric Gastroenterology, Hepatology & Nutrition
- 제4권2호
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- Pages.243-248
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- 2001
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- 2234-8646(pISSN)
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- 2234-8840(eISSN)
면역글로불린 A 및 $G_2$ , $G_4$ 결핍에 동반된 만성 난치성 설사 1례
A Case of Chronic Intractable Diarrhea with IgA, $IgG_2$ and $IgG_4$ Deficiency
- 안성연 (부산대학교 의과대학 소아과학교실) ;
- 김영미 (부산대학교 의과대학 소아과학교실) ;
- 남상욱 (부산대학교 의과대학 소아과학교실) ;
- 박재홍 (부산대학교 의과대학 소아과학교실) ;
- 이창훈 (부산대학교 의과대학 병리학교실)
- Ahn, Sung-Ryon (Department of Pediatrics, College of Medicine, Pusan National University Hospital) ;
- Kim, Young-Mi (Department of Pediatrics, College of Medicine, Pusan National University Hospital) ;
- Nam, Sang-Ook (Department of Pediatrics, College of Medicine, Pusan National University Hospital) ;
- Park, Jae-Hong (Department of Pediatrics, College of Medicine, Pusan National University Hospital) ;
- Lee, Chang-Hoon (Department of Pathology, College of Medicine, Pusan National University Hospital)
- 투고 : 2001.08.20
- 심사 : 2001.09.05
- 발행 : 2001.09.30
초록
저자들은 생후 2개월부터 지속되는 만성 설사를 주소로 내원한 환아에서 면역글로불린 정량 검사상 IgA의 결핍과 함께
In most cases, acute diarrhea in childhood heals spontaneously, but it may become the form of chronic diarrhea in immunodeficient children and then cause weight loss, dehydration, malabsorption and malnutrition. The immunodeficient diseases associated with chronic diarrhea include severe combined immunodeficiency syndrome, common variable immunodeficiency, acquired immunodeficiency syndrome, agammaglobulinemia or selective IgA deficiency. IgA deficiency is the most common primary immunodeficiency. Because many IgA deficient individuals seem to have compensated for their deficiency with increased IgM production and various nonimmunologic factors, the incidence of gastrointestinal involvement is not prominent. Some of those with IgA deficiency and recurrent infections have been found to also have IgG subclass deficiency. IgA deficiency with