Journal of Periodontal and Implant Science

Korean Academy of Periodontology (대한치주과학회)
권호 표지

Biodegradability of porous Calcium Polyphosphate

다공질 Calcium Polyphosphate의 생분해성에 관한 연구

  • Yang, Seung-Min (Department of Periodontology, College of Dentistry, Seoul National University, Department of Periodontics, The Institute of Oral Health Science, Samsung Medical Center) ;
  • Lee, Young-Kyoo (Department of Periodontics, The Institute of Oral Health Science, Samsung Medical Center) ;
  • Han, Eun-Young (Department of Periodontology, College of Dentistry, Seoul National University) ;
  • Kim, Seok-Young (Department of Material Technology, College of Engineering, Yeungnam University) ;
  • Kye, Seung-Beom (Department of Periodontics, The Institute of Oral Health Science, Samsung Medical Center, School of Medicine, Sungkyunkwan University) ;
  • Lee, Seung-Jin (Department of industrial Pharmacy, College of Pharmacy, Ewha Womans University) ;
  • Lee, Yong-Moo (Department of Periodontology, College of Dentistry, Seoul National University) ;
  • Ku, Young (Department of Periodontology, College of Dentistry, Seoul National University) ;
  • Han, Soo-Boo (Department of Periodontology, College of Dentistry, Seoul National University) ;
  • Chung, Chong-Pyoung (Department of Periodontology, College of Dentistry, Seoul National University) ;
  • Choi, Sang-Mook (Department of Periodontology, College of Dentistry, Seoul National University) ;
  • Rhyu, In-Chul (Department of Periodontology, College of Dentistry, Seoul National University)
  • 양승민 (서울대학교 치과대학 치주과학교실, 삼성의료원 치과진료부 치주과) ;
  • 이영규 (삼성의료원 치과진료부 치주과) ;
  • 한은영 (서울대학교 치과대학 치주과학교실) ;
  • 김석영 (영남대학교 공과대학 재료금속공학부) ;
  • 계승법 (성균관대학교 의과대학 삼성의료원 치과진료부 치주과) ;
  • 이승진 (이화여자대학교 약학대학 물리약학교실) ;
  • 이용무 (서울대학교 치과대학 치주과학교실) ;
  • 구영 (서울대학교 치과대학 치주과학교실) ;
  • 한수부 (서울대학교 치과대학 치주과학교실) ;
  • 정종평 (서울대학교 치과대학 치주과학교실) ;
  • 최상묵 (서울대학교 치과대학 치주과학교실) ;
  • 류인철 (서울대학교 치과대학 치주과학교실)
  • Published : 2001.09.30
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Abstract

The purpose of this study is to evaluate the bioresorbability of Calcium Polyphosphate added with $Na_2O$ and chitosan. Though calcium phosphate ceramics meet some of the needs for bone replacement, they have some limitation of unresorbability and fibrous encapsulation without direct bone apposition during bone remodelling. To solve these problem, we developed a new ceramic, calcium polyphosphate(CPP), and report the biologic response to CPP in extraction sites of beagle dog. Porous CPP granules were prepared by condensation of anhydrous $Ca(H_2PO_4)_2$ to form non-crystalline $Ca(PO_3)_2$. CPP granules added with $Na_2O$ and chitosan were implanted in extraction sockets and histologic observation were performed at 12 weeks later. Histologic observation at 12 weeks revealed that CPP matrix were mingled with and directly apposed to new bone without any intervention of fibrous connective tissue. CPP granules added with chitosan were well adatped without any adverse tissue reaction and resorbed slowly and spontaneously. CPP granules added with $Na_2O$ and chitosan show multinucleated giant cells and osteoblast-like cells around grafted material and newly formed bone. This result revealed that CPP, regardless of its additive component, had a high affinity for bone and had been resorbed slowly. From this results, it was suggested that CPP is promising ceramic as a bone substitute and addition of $Na_2O$ and chitosan help biodegradation. In further study , it will be determined which concentration of $Na_2O$ help biodegradation and the other additive components increase the degradation rate.

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