Korean Journal of Radiology

  • 제2권4호
  • /
  • Pages.239-242
  • /
  • 2001
  • /
  • 1229-6929(pISSN)
  • /
  • 2005-8330(eISSN)
대한영상의학회 (The Korean Society of Radiology)
권호 표지

Localized Proton MR Spectroscopic Detection of Nonketotic Hyperglycinemia in an Infant

  • Choong-Gon Choi (Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Ho Kyu Lee (Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Jong-Hyun Yoon (Department of Radiology, Asan Medical Center, University of Ulsan College of Medicine)
  • 투고 : 2001.05.18
  • 심사 : 2001.10.05
  • 발행 : 2001.12.31
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초록

Nonketotic hyperglycinemia (NKH) is a rare metabolic brain disease caused by deficient activity of the glycine cleveage system. Localized proton MR spectroscopy (echo-time 166 msec), performed in an infant with the typical clinical and biochemical features of neonatal NKH, showed a markedly increased peak intensity at 3.55 ppm, which was assigned to glycine. Serial proton MR spectrosocpic studies indicated that glycine/choline and glycine/total creatine ratios correlated closely with the patient's clinical course. Proton MR spectroscopy was useful for the non-invasive detection and monitoring of cerebral glycine levels in this infant with NKH.

키워드

참고문헌

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