Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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MR Imaging-Histopathologic Correlation of Radiofrequency Thermal Ablation Lesion in a Rabbit Liver Model: Observation during Acute and Chronic Stages

  • Jong Deok Lee (Department of Diagnostic Radiology, Chonbuk National University Medical School) ;
  • Jeong Min Lee (Department of Diagnostic Radiology, Chonbuk National University Medical School) ;
  • Sang Won Kim (Department of Diagnostic Radiology, Chonbuk National University Medical School) ;
  • Chong Soo Kim (Department of Diagnostic Radiology, Chonbuk National University Medical School) ;
  • Woo Sung Mun (Department of Surgical Pathology, Chonbuk National University Medical School)
  • Received : 2001.02.19
  • Accepted : 2001.07.12
  • Published : 2001.09.30
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Abstract

Objective: To determine the ability of MR imaging to detect the pathological changes occurring in radiofrequency (RF) thermal lesions and to assess its accuracy in revealing the extent of tissue necrosis. Materials and Methods: Using an RF electrode, thermal lesions were created in the livers of 18 rabbits. The procedure involved three phases. In the acute phase, six animals were killed the day after performing thermal ablation with RF energy, and two on day 3. In the subacute and chronic phases, eight rabbits underwent percutaneous hepatic RF ablation. After performing MR imaging, two animals were sacrificed at 1, 2, 4, and 7 weeks after the procedure, and MRpathologic correlation was performed. Results: In the acute phase, the thermal ablation lesions appeared at gross examination as well-circumscribed, necrotic areas, representing early change in the coagulative necrosis seen at microscopic examination. They were hypointense on T2-weighted images, and hyperintense on T1-weighted images. Gadolinium-enhanced MR imaging showed that a thin hyperemic rim surrounded the central coagulative necrosis. In the subacute phase, ablated lesions also showed extensive coagulative necrosis and marked inflammation at microscopic examination. Beyond two weeks, the lesions showed gradual resorption of the necrotic area, with a peripheral fibrovascular rim. The size of lesions measured by MR imaging correlated well with the findings at gross pathologic examination. Conclusion: MR imaging effectively demonstrates the histopathological tissue change occurring after thermal ablation, and accurately determines the extent of the target area.

Keywords

Acknowledgement

The authors wish to thank Cheol-Ho Kim, M.D. and Jae-Hyuk Yun for their assistance in animal observation and anesthesia, as well as Dae-Hyun Kim and Hyun-Keun Lee for their outstanding support regarding MR imaging procedures.

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