Korean Journal of Radiology

The Korean Society of Radiology (대한영상의학회)
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Perfusion MR Imaging in Gliomas: Comparison with Histologic Tumor Grade

  • Sun Joo Lee (Department of Radiology, Gyeongsang National University College of Medicine) ;
  • Jae Hyoung Kim (Department of Radiology, Gyeongsang National University College of Medicine) ;
  • Young Mee Kim (Department of Radiology, Gyeongsang National University College of Medicine) ;
  • Gyung Kyu Lee (Department of Radiology, Gyeongsang National University College of Medicine) ;
  • Eun Ja Lee (Department of Radiology, Gyeongsang National University College of Medicine) ;
  • In Sung Park (Department of Electronic Engineering, Gyeongsang National University College of Engineering) ;
  • Jin-Myung Jung (Department of Electronic Engineering, Gyeongsang National University College of Engineering) ;
  • Kyeong Hun Kang (Department of Neurosurgery, Gyeongsang National University College of Medicine) ;
  • Taemin Shin (Department of Neurosurgery, Gyeongsang National University College of Medicine)
  • Received : 2000.10.19
  • Accepted : 2000.12.20
  • Published : 2001.03.31
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Abstract

Objective: To determine the usefulness of perfusion MR imaging in assessing the histologic grade of cerebral gliomas. Materials and Methods: In order to determine relative cerebral blood volume (rCBV), 22 patients with pathologically proven gliomas (9 glioblastomas, 9 anaplastic gliomas and 4 low-grade gliomas) underwent dynamic contrast-enhanced T2*-weighted and conventional T1- and T2-weighted imaging. rCBV maps were obtained by fitting a gamma-variate function to the contrast material concentration versus time curve. rCBV ratios between tumor and normal white matter (maximum rCBV of tumor / rCBV of contralateral white matter) were calculated and compared between glioblastomas, anaplastic gliomas and low-grade gliomas. Results: Mean rCBV ratios were 4.90°±1.01 for glioblastomas, 3.97°±0.56 for anaplastic gliomas and 1.75°±1.51 for low-grade gliomas, and were thus significantly different; p < .05 between glioblastomas and anaplastic gliomas, p < .05 between anaplastic gliomas and low-grade gliomas, p < .01 between glioblastomas and low-grade gliomas. The rCBV ratio cutoff value which permitted discrimination between high-grade (glioblastomas and anaplastic gliomas) and low-grade gliomas was 2.60, and the sensitivity and specificity of this value were 100% and 75%, respectively. Conclusion: Perfusion MR imaging is a useful and reliable technique for estimating the histologic grade of gliomas.

Keywords

Acknowledgement

This study was supported by grant number HMP-97-NM-2-0038 from the Good Health R&D Project, Ministry of Health and Welfare, and the Brain Korea 21 Project, Ministry of Education, South Korea.

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