The Journal of Korean Physical Therapy

The Korean Society of Physical Therapy (대한물리치료학회)
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The Role of Survival Motor Neuron Protein associated with Function of Spinal Motor Neuron

척수 운동신경원의 기능과 관련된 생존운동신경원 단백질의 역할

  • Song, Ju-Young (Major in Physical Therapy, Department of Rehabilitation Science, Graduate School, Taegu University) ;
  • Kown, Young-Shil (Major in Physical Therapy, Department of Rehabilitation Science, Graduate School, Taegu University) ;
  • Nam, Ki-Won (Major in Physical Therapy, Department of Rehabilitation Science, Graduate School, Taegu University) ;
  • Song, Ju-Min (Major in Physical Therapy, Department of Rehabilitation Science, Graduate School, Taegu University) ;
  • Kim, Dong-Hyun (Major in Physical Therapy, Department of Rehabilitation Science, Graduate School, Taegu University) ;
  • Kim, Suk-Bum (Major in Physical Therapy, Department of Rehabilitation Science, Graduate School, Taegu University) ;
  • Moon, Dong-Chul (Major in Physical Therapy, Department of Rehabilitation Science, Graduate School, Taegu University) ;
  • Choi, Ji-Ho (Department of Physical Therapy, Yeongdong Junior College) ;
  • Kim, Jin-Sang (Department of Physical Therapy, College of Rehabilitation Science, Taegu University)
  • 송주영 (대구대학교 대학원 재활과학과 물리치료) ;
  • 권영실 (대구대학교 대학원 재활과학과 물리치료) ;
  • 남기원 (대구대학교 대학원 재활과학과 물리치료) ;
  • 송주민 (대구대학교 대학원 재활과학과 물리치료) ;
  • 김동현 (대구대학교 대학원 재활과학과 물리치료) ;
  • 김석범 (대구대학교 대학원 재활과학과 물리치료) ;
  • 문동철 (대구대학교 대학원 재활과학과 물리치료) ;
  • 최진호 (영동전문대학 물리치료과) ;
  • 김진상 (대구대학교 재활과학대학 물리치료학과)
  • Published : 2001.09.24
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Abstract

This review highlights the ontogenesis and the differentiation of motor neuron in spinal cord, and introduce the survival motor neuron(SMN) which is associated with growth and survival of motor neurons. The differentiation of floor plate cells and motor neurons in the vertebrate neural tube appears to be induced by signals from the notochord. This signal is Sonic hedgehog(Shh). The early development of motor neurons involves the inductive action of Shh. The SMN gene is essential for embryonic viability. SMN mRNA is also expressed in virtually all cell types in spinal cord, including large motor neurons. The SMN protein is involved in RNA processing and during early embryonic development is necessary fer cell survival. Two SMN genes are present in 5q 13 in humans: the telomeric gene(SMNt), which is the SMA-determining gene, and the centromeric analog gene(SMNc). The majority of transcripts from the SMNt gene are full length but, major transcripts of the SMNc gene have a high degrees of alternative splicing and tend to have little or no exon 7. The SMN is involved in the RNA processing(the biogenesis of snRNPs and pre-mRNA splicing), the anti-apoptotic effects, and regulating gene expression.

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