Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
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EFFECTS OF LOCAL APPLICATION OF HEPARIN AND VASCULAR FREEZING ON THROMBOSIS OF MICROVASCULAR ANASTOMOSES IN THE RABBIT FEMORAL VEIN

가토 대퇴정맥에서 헤파린 국소 적용과 혈관냉동이 미세혈관문합부 혈전 형성에 미치는 영향

  • Kim, Ji-Young (Department of Oral & Maxillofacial Surgery, Dental Science Research Institute, College of Dentistry, Chonnam National University) ;
  • Oh, Hee-Kyun (Department of Oral & Maxillofacial Surgery, Dental Science Research Institute, College of Dentistry, Chonnam National University) ;
  • Ryu, Sun-Youl (Department of Oral & Maxillofacial Surgery, Dental Science Research Institute, College of Dentistry, Chonnam National University) ;
  • Kim, Sun-Hun (Department of Oral Anatomy, Dental Science Research Institute, College of Dentistry, Chonnam National University)
  • 김지영 (전남대학교 치과대학 구강악안면외과학교실, 치의학연구소) ;
  • 오희균 (전남대학교 치과대학 구강악안면외과학교실, 치의학연구소) ;
  • 유선열 (전남대학교 치과대학 구강악안면외과학교실, 치의학연구소) ;
  • 김선헌 (전남대학교 치과대학 구강해부학교실, 치의학연구소)
  • Published : 2001.04.30
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Abstract

The effect of topical heparin application and vascular freezing on thrombosis was evaluated in the femoral vein of rabbits. The femoral veins were crushed, incised transversely and treated by 4 different ways; 1) group 1, heparin treated only, 2) group 2, frozen only, 3) group 3, heparin treated and frozen, 4) group 4, treated with saline as control. The patency was evaluated by empty-and-refill test and thrombus formation was judged by stereoscopic and SEM observation. The results obtained were as follows: 1. Thirty minutes after suture, the patency was more improved in the three groups than the control, but there was no significant difference among groups. 2. Three days after suture, the patency was more improved in the three groups than the control, and was prominent in group 1 and group 3 (P<0.05). 3. Significantly reduced thrombus could be seen in most case of group 3. These results suggest that topical application of heparin and vascular freezing is effective in reducing thrombus formation in microsurgery of vein.

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