The Korean Journal of Nuclear Medicine (대한핵의학회지)
- Volume 35 Issue 4
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- Pages.231-240
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- 2001
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- 1225-6714(pISSN)
Changes of Regional Cerebral Glucose Metabolism in Normal Aging Process : A Study With EDG PET
정상적인 노화 과정에서 국소뇌포도당대사의 변화: FDG PET 연구
- Yoon, Joon-Kee (Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
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Kim, Sang-Eun
(Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
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Lee, Kyung-Han
(Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
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Choi, Yong
(Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
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Choe, Yearn-Seong
(Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
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Kim, Byung-Tae
(Department of Nuclear Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
- 윤준기 (성균관대학교 의과대학 삼성서울병원 핵의학교실) ;
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김상은
(성균관대학교 의과대학 삼성서울병원 핵의학교실) ;
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이경한
(성균관대학교 의과대학 삼성서울병원 핵의학교실) ;
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최용
(성균관대학교 의과대학 삼성서울병원 핵의학교실) ;
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최연성
(성균관대학교 의과대학 삼성서울병원 핵의학교실) ;
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김병태
(성균관대학교 의과대학 삼성서울병원 핵의학교실)
- Published : 2001.08.30
Abstract
Purpose: Normal aging results in detectable changes in the brain structure and function. We evaluated the changes of regional cerebral glucose metabolism in the normal aging process with FDG PET. Materials and Methods: Brain PET images were obtained in 44 healthy volunteers (age range 20-69 'y'; M:F = 29:15) who had no history of neuropsychiatric disorders. On 6 representative transaxial images, ROIs were drawn in the cortical and subcortical areas. Regional FDG uptake was normalized using whole brain uptake to adjust for the injection dose and correct for nonspecific declines of glucose metabolism affecting all brain areas equally. Results: In the prefrontal, temporoparietal and primary sensorimotor cortex, the normalized FDG uptake (NFU) reached a peak in subjects in their 30s. The NFU in the prefrontal and primary sensorimotor cortex declined with age after 30s at a rate of 3.15%/decade and 1.93%/decade, respectively. However, the NFU in the temporoparietal cortex did not change significantly with age after 30s. The anterior (prefrontal) posterior (temporoparietal) gradient peaked in subjects in their 30s and declined with age thereafter at a rate of 2.35%/decade. The NFU in the caudate nucleus was decreased with age after 20s at a rate of 2.39%/decade. On the primary visual cortex, putamen, and thalamus, the NFU values did not change significantly throughout the ages covered. These patterns were not significantly different between right and left cerebral hemispheres. Of interest was that the NFU in the left cerebellar cortex was increased with age after 20s at a rate of 2.86%/decade. Conclusion: These data demonstrate regional variation of the age-related changes in the cerebral glucose metabolism, with the most prominent age-related decline of metabolism in the prefrontal cortex. The increase in the cerebellar metabolism with age might reflect a process of neuronal plasticity associated with aging.