Journal of the Korean Chemical Society (대한화학회지)

Korean Chemical Society (대한화학회)
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Synthesis of Pyrazolylquinoxalines and Pyrazolylpyrrolo[1,2-a]-quinoxalines

Pyrazolylquinoxaline류 및 Pyrazolylpyrrolo[1,2-a]-quinoxaline류의 합성

  • Kim, Ho Sik (Department of Chemistry, Catholic University of Taegu) ;
  • Lee, Seong Uk (Department of Chemistry, Catholic University of Taegu) ;
  • Jeong, Won Young (Department of Chemistry, Catholic University of Taegu) ;
  • Han, Sung Wook (Department of Environmental Engineering, Kyungwoon University) ;
  • Kim, Dong Il (Department of Environmental Engineering, Kyungwoon University) ;
  • Yoshihisa Kurasawa (School of Pharmaceutical Sciences, Kitasato University)
  • 김호식 (대구가톨릭대학교 자연과학대학 화학과) ;
  • 이성욱 (대구가톨릭대학교 자연과학대학 화학과) ;
  • 정원영 (대구가톨릭대학교 자연과학대학 화학과) ;
  • 한성욱 (경운대학교 환경공학과) ;
  • 김동일 (경운대학교 환경공학과) ;
  • Published : 20010800
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Abstract

The reaction of 6-chloro-2-hydrazinoquinoxaline(4) or 6-chloro-2-hydrazinoquinoxaline 4-oxide(7) with alkyl (ethoxymethylene)cyanoacetates gave pyrazolylquinoxalines(5, 8). The reaction of compounds 8 with dimethyl acetylenedicarboxylate resulted in the 1,3-dipolar cycloaddition reaction and then ring transformation to afford pyrazolylpyrrolo[1,2-a]quinoxalines(9).

6-Chloro-2-hydrazinoquinoxaline(4) 또는 6-chloro-hydrazinoquinoxaline 4-oxide(7)를 alkyl(ethoxymethylene)cyanoacetate류와 반응시켜 prazolylquinoxaline류(5,8)를 합성하였다. 그리고 화합물 8을 dimethyl acethylenedicarboxylate와 반응시켜 1,3-쌍극성 고 리와 첨가반응과 고리변환에 의하여 pyrazolylpyrrolo[1,2-a]quinoxaline류(9)를 합성하였다.

Keywords

References

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