Bulletin of the Korean Chemical Society

  • 제22권11호
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  • Pages.1217-1223
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  • 2001
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Synthesis and SAR of Benzimidazole Derivatives Containing Oxycyclic Pyridine as a Gastric $H^+/K^+$-ATPase Inhibitors

  • 발행 : 20011100
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초록

A series of benzimidazole derivatives containing oxycyclic pyridine was prepared and evaluated for their gastric H+ /K+ -ATPase inhibitory activity. Several of the synthesized compound exhibited potent antisecretion in pylorus-ligated rats when administered intradoudenally. Their inhibitory activities were equivalent or comparable to omeprazole.

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피인용 문헌

  1. ChemInform Abstract: Synthesis and SAR of Benzimidazole Derivatives Containing Oxycyclic Pyridine as a Gastric H+/K+-ATPase Inhibitors. vol.33, pp.29, 2001, https://doi.org/10.1002/chin.200229162
  2. Synthesis and antimicrobial activity of 5-hydroxymethyl- 8-methyl-2-(N-arylimino)-pyrano[2,3-c]pyridine-3-(N-aryl)-carboxamides vol.15, pp.24, 2001, https://doi.org/10.1016/j.bmcl.2005.08.081
  3. Copper- and Ligand-free Heteroannulation ofo-Halohydroxypyridine with Terminal Alkynes Using Pd/C Catalyst: One-Pot Synthesis of 2-Substituted Furopyridines and their Functionalization vol.36, pp.1, 2001, https://doi.org/10.1002/bkcs.10052
  4. Elaboration of Furopyridine Scaffolds vol.2015, pp.11, 2001, https://doi.org/10.1002/ejoc.201403412
  5. Zirconium based porous coordination polymer (PCP) bearing organocatalytic ligand: A promising dual catalytic center for ultrasonic heterocycle synthesis vol.58, pp.None, 2019, https://doi.org/10.1016/j.ultsonch.2019.104653
  6. A convenient method for synthesis of terpyridines via a cooperative vinylogous anomeric based oxidation vol.10, pp.43, 2001, https://doi.org/10.1039/d0ra04461j