Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
권호 표지

A Study of Protein S Deficiency in Antiphospholipid Syndrome

항인지질증후군에서 S단백질 결핍증에 대한 연구

  • Nam, Yoon-Sung (Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University) ;
  • Kim, Nam-Keun (Department of Genetics, College of Medicine, Pocheon CHA University) ;
  • Kang, Myung-Seo (Department of Clinical Pathology, College of Medicine, Pocheon CHA University) ;
  • Oh, Do-Yeon (Department of Internal Medicine, College of Medicine, Pocheon CHA University) ;
  • Cha, Kwang-Yul (Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University)
  • 남윤성 (포천중문의과대학 산부인과학교실) ;
  • 김남근 (포천중문의과대학 유전학연구실) ;
  • 강명서 (포천중문의과대학 임상병리학교실) ;
  • 오도연 (포천중문의과대학 내과학교실) ;
  • 차광열 (포천중문의과대학 산부인과학교실)
  • Published : 2001.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objective: To evaluate the abnormality of protein S in patients with recurrent spontaneous abortion due to antiphospholipid syndrome. Material and Method: Antigen and activity of protein S were analyzed by enzyme immunoassay and clotting method, respectively. Results: Of 18 patients with antiphospholipid syndrome, 4 patients were found to have no abnormality of protein S. There were 14 cases of protein S abnormality. Among them, there were 8 cases of type 1, 1 case of type 2, and 5 cases of type 3 protein S deficiency. Conclusion: So in the workup of patients with recurrent spontaneous abortion due to antiphospholipid syndrome, the evaluation for protein S is required.

Keywords