Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
권호 표지

A Study of Factor XII Deficiency in Recurrent Spontaneous Abortion

반복자연유산에서 12번 응고인자 결핍증에 대한 연구

  • Nam, Yoon-Sung (Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University) ;
  • Kim, Nam-Keun (Department of Genetics, College of Medicine, Pocheon CHA University) ;
  • Lee, Su-Man (Department of Genetics, College of Medicine, Pocheon CHA University) ;
  • Kang, Myung-Seo (Department of Clinical Pathology, College of Medicine, Pocheon CHA University) ;
  • Oh, Do-Yeon (Department of Internal Medicine, College of Medicine, Pocheon CHA University) ;
  • Cha, Kwang-Yul (Department of Obstetrics and Gynecology, College of Medicine, Pocheon CHA University)
  • 남윤성 (포천중문의과대학 산부인과학교실) ;
  • 김남근 (포천중문의과대학 유전학연구실) ;
  • 이수만 (포천중문의과대학 유전학연구실) ;
  • 강명서 (포천중문의과대학 임상병리학교실) ;
  • 오도연 (포천중문의과대학 내과학교실) ;
  • 차광렬 (포천중문의과대학 산부인과학교실)
  • Published : 2001.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objective : To evaluate factor XII deficiency in patients with recurrent spontaneous abortion and its relation to aPTT. Material and Method: Factor XII was analyzed by clotting method. Results: Of 70 patients with recurrent spontaneous abortion, there were 35 cases of factor XII deficiency. Among them, there were only 3 cases of prolonged aPTT. Conclusions: It is still unclear whether factor XII deficiency is related to recurrent spontaneous abortion. Molecular approaches should be used to understand further the causal relationship. But based on this result, in the workup of patients with recurrent spontaneous abortion, factor XII should be included. aPTT is not likely to represent the abnormality of factor XII.

Keywords