Toxicological Research
- Volume 17 Issue 1
- /
- Pages.65-71
- /
- 2001
- /
- 1976-8257(pISSN)
- /
- 2234-2753(eISSN)
Modification of Estrogenic Effect of Nonylphenol Combined with DEHP in Yeast-based Bioassay
형질전환효모를 이용한 내분비계장애물질검색과 Nonylphenol의 Estrogen 유사작용에 대한 DEHP의 상협작용
Abstract
The key targets of endocrine disruptors are nuclear hormone receptors, which bind to steroid hormones and regulate their gene transcription. A yeast-based steroid hormone receptor gene trascription assay was previously developed for the evaluation of chemicals with endocrine modulating activity. The yeast transformants used in this assay contain the human estrogen receptor along with the appropriate steroid response elements upstream of the