Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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The Effect of Repeated Application of A Mouthwash to the Mucosa of the Hamster Cheek Pouch

햄스터에서 에이 마우스워시의 구강점막자극시험

  • 강경선 (서울대학교 수의과대학 수의공중보건학교실) ;
  • 제정환 (서울대학교 수의과대학 수의공중보건학교실) ;
  • 김형섭 (서울대학교 수의과대학 수의공중보건학교실) ;
  • 김경배 (서울대학교 수의과대학 수의공중보건학교실) ;
  • 이지해 (서울대학교 수의과대학 수의공중보건학교실) ;
  • 조성대 (서울대학교 수의과대학 수의공중보건학교실) ;
  • 조종호 (서울대학교 수의과대학 수의공중보건학교실) ;
  • 김배환 ((주) 태평양기술연구원) ;
  • 이병렬 ((주) 태평양기술연구원)
  • Published : 2001.03.01
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Abstract

This study was carried out to evaluate the irritant potential of A mouthwash in hamster cheek pouch. The test substances were applied twice daily to right pouches of hamsters for 14 consecutive days. Animals were administered with A mouthwash, Listerine, saline and control solution, respectively. In order to evaluate the irritant potential in mucosa of hamster cheek pouch, we observed clinical signs, mortality, body weight changes and gross and histopathological findings for 14 days. In all groups, there were neither dead animals nor significant changes of body weights. In addition, there were no differences between saline and A mouthwash treated group in gross and histopathological findings. Therefore, these results suggest that there was no irritant potential of A mouthwash in hamster cheek pouch.

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