Toxicological Research
- Volume 17 Issue 1
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- Pages.7-9
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- 2001
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
Non-polar Solvents (Toluene and Styrene) Enhance Methanol Skin Absorption
- Lim, Cheol-Hong (Center for Occupational Toxicology, Occupational Safety & Health Research Institute, Korea Occupational Safety and Health Agency) ;
- Yu, Il-Je (Center for Occupational Toxicology, Occupational Safety & Health Research Institute, Korea Occupational Safety and Health Agency)
- Published : 2001.03.01
Abstract
The quantitative assessment of the penetration of organic solvents through skin is necessary for the evaluation of health hazards in occupational environments. We investigated the rate of dermal penetration when mixed or single forms of organic solvents were placed into a diffusion cell in vitro or into an experimental animal in vivo. The diffusion rates of methanol. toluene, and styrene were 6.07, 0.129, and 0.046 mg/