Toxicological Research
- 제17권
- /
- Pages.201-203
- /
- 2001
- /
- 1976-8257(pISSN)
- /
- 2234-2753(eISSN)
Establishment of Immunotoxicology Evaluation Procedures for Pharmaceuticals
- Nakamura, Kazuichi (Immunotoxicology Working Group. Preclinical Evaluation Subcommittee. Drug Evaluation Committee. Japan Pharmaceutical Manufacturers Association)
- 발행 : 2001.07.01
초록
The Japan Pharmaceutical Manufacturers Association. with the cooperation of the Japan Association of Contract Laboratories for Safety Evaluation. launched a collaborative study with 38 companies aimed at elucidating the correlation between histopathological/hematological findings and immune function. Seven substances were individually administered to Crj : CD (SD)IGS rats for 14 or 28 days. Their immunotoxicity was assessed by histopathology. hematology. plaque-forming cell assay. enzyme-linked immunosorbent assay of serum antibody to sheep red blood cells. and flow cytometry. Appropriate procedures for immunotoxicology evaluation of pharmaceuticals were considered.
키워드