한국자기공명학회논문지 (Journal of the Korean Magnetic Resonance Society)
- 제5권2호
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- Pages.118-129
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- 2001
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- 1226-6531(pISSN)
NMR Study on Binding Interactions of Cationic Porphyrin Derivatives with double helical $d(CGCGAATTCGCG)_2$
- Huh, Sungho (Department of Biochemistry, Chungnam National University) ;
- Hong, Seokjoo (Department of Biochemistry, Chungnam National University)
- 발행 : 2001.12.01
초록
Binding interactions of cationic porphyrins, T4MPyP and TMAP with DNA oligomer d(CGCGAATTCGCG), were studied with NMR spectroscopy, W and CD spectroscopic method. Two porphyrins showed significant differences in NMR, UV and CD data upon binding to DNA. T4MPyP was considered to position more closely to DNA bases through partial intercalation as well as ionic intercalation between the positive charges of porphyrin and phosphate group of DNA at 5’-GC-3’steps. Contrast to this, TMAP was thought to bind to phosphate of DNA more or less outside of the groove.
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