한국환경성돌연변이발암원학회지 (Environmental Mutagens and Carcinogens)
- 제21권2호
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- Pages.122-127
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- 2001
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- 1225-6307(pISSN)
Rat에서의 Octylphenol의 독성동태 연구
Toxicokinetics of 4-tert-octylphenol in rats
초록
4-tert-octylphenol (OP) is a surfactant additive widely used in the manufacture of a variety of detergents and plastic products. Also, OP is known to have estrogenic activity by interacting with development and functions of endocrine system. This study was carried out to obtain toxicokinetic parameters of OP in male Sprague-Dawley rats. Male rats were administered OP, by either single oral (gavage) applications of 50, 100 or 200 mg/kg body weight. or a single intravenous injections of 1, 5 or 10 mg/kg body weight. Blood samples taken at several time intervals after administration were obtained from the femoral artery. Analysis of blood samples for OP was performed by gas chromatography mass spectrometry (GC/MS). The detection limit of OP was 1.9 ng/