Journal of Photoscience

Korean Society of Photoscience (한국광과학회)
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Three-Dimensional Quantitative Structure Activity Relationship Studies on the Flavone Cytotoxicity and Binding to Tubulin

  • Kim, Ja-Hong (Department of Chemistry Education, Chonbuk National University) ;
  • Sohn, Sung-Ho (Department of Chemistry, Woosuk University) ;
  • Hong, Sun-Wan (Department of Chemistry, Woosuk University)
  • Published : 2001.09.01
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Abstract

Three-Dimensional Quantitative Structure-Activity Relationship(QSAR) has been investigated over 67 flavonoids to correlate and predict GI$\sub$50/ values. The partial least-squares(PLS) model was performed to calculate the activity of each derivatives, and this was compared with the actual value. The results of the cross-validated(${\gamma}$$^2$=0.997) values show that cytotoxic activities play an important role which is in good agreement with the observed GI$\sub$50/ values.

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