YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

The Water Extract of Boswellia carterii Induces Apoptosis in Human Leukemia HL-60 Cells

유향 물 추출물의 HL-60 혈액암세포에서 세포사멸 유도효과

  • 박래길 (원광대학교 한의학전문대학원 신약개발학과) ;
  • 오광록 (우석대학교 한의과대학) ;
  • 이광규 (우석대학교 한의과대학) ;
  • 문연자 (원광대학교 한의학전문대학원 신약개발학과) ;
  • 김정훈 (원광대학교 한의학전문대학원 신약개발학과)
  • Published : 2001.04.01
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Abstract

The possible mechanism of the antiproliferative and apoptotic effects of Boswellia carterri water extract were studied in HL-60 human leukemia cells. The cytotoxicity of HL-60 cells after the treatment of Boswellia carterii water extract showed dose- and time-dependent manner. The apoptotic effect of 300 $\mu$g/ml Boswellia carterii water extract was demonstrated by DNA laddering. The activity of caspase 3-1ike protease was markedly increased in HL-60 cells treated with Boswellia carterii water extract. Furthermore, the level of Bcl-2 was time-dependently reduced, whereas Bax protein level was enhanced by Boswellia carterii water extract treatment. In conclusion, our results suggest that apoptotic effect of Boswellia carterii water extract may partly mediated through activations of caspase-3 activity and Bax expression, and inhibition of Bcl-2 expression.

Keywords

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