YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Mechanism of Increased Adrenergic Activities in Hypertension Induced by Chronic Inhibition of NOS

NOS만성억제로 인한 고혈압에서 아드레날린성 활성증가기전

  • Published : 2001.02.01
Download PDF
⟨ Previous Next ⟩

Abstract

Nitric oxide is a tonically produced vasodilator that maintains blood pressure in the normal animal. The chronic inhibition of nitric oxide synthase (NOS) elicits the hypertension in rats. However, the mechanism of hypertension induced by chronic inhibition of NOS is not clear. Thus, to clarify the mechanism of the occurance of hypertension, the changes in $\alpha$-adrenergic systems in rats treated with NOS inhibitors for 21 days were examined. Chronic administration of L-NAME significantly increased in the basal blood pressure, but chronic administration of 7-nitroindazole did not. Phenylephrine and G-protein stimulator elicited the more potent contraction in the aorta of the L-NAME-induced hypertensive rats. However when the contractile responses by phenylephrine and G-protein stimulator were calculated the proportion to the contraction by 25 mM KCL, there was no difference between the vehicle-treated rats and the L-NAME-treated rats. The density of $\alpha$-adrenergic receptors in aortic tissue was not changed by the chronic inhibition of NOS. These results suggest that hypertension induced by chronic inhibition of NOS is due to the inhibition of eNOS and the increased responses to the adrenergic drugs are due to the changes of the intracellular contactile mechanism of aortic tissue rather than the changes of receptor density.

Keywords

References

  1. Pharmacol. Rev v.43 Nitric oxide: physiology, pathophysiology and pharmacology Moncada, S., Palmer, R. M. J;Higgs, E. A
  2. Neuron v.8 Nitric oxide, a novel neuronal messenger Bredit, D.S;Snyder, S.H
  3. Engl. J. Med v.329 The L-arginine-nitric oxide pathway. N Moncada, S;Higgs, E.A
  4. Ann. Intern. Med v.120 Nitric oxide: a physiologic messenger Lowenstein, C. J., Dinerman, J. L;Snyder, S. H
  5. Circ. Res v.62 Cyclic guanosine monophosphate-enhanced sequestration of Ca2+ by sarcoplasmic reticulum in vascular smooth muscle Twort, C. H. C;van Breemen, C
  6. Br. J. Pharmacol v.97 Actions of guanine nucleotides and cyclic nucleotides on calcium stores in single patch clamped smooth muscle cells from rabbit portal vein Komori, S;Bolton, T. B
  7. J. Biol. Chem v.265 Mechanism of cyclic GMP inhibition of inositol phosphate formation in rat aorta segment and cultured bovine aortic smooth muscle cells Hirata, M., Kohse, K. P., Chang, C. H., Ikebe, T. J;Murad, F
  8. Proc. Natl. Acad. Sci v.90 Transfected cGMP-dependent protein kinase suppresses calcium transients by inhibition of inositol 1,4,5-triphosphate production Ruth, P., Wang, G. X., Boekhoff, I., May, B., Pfeifer, A., Penner, R., Korth, M., Breer, M;Hoffmann, F
  9. Sci. Am v.266 Biological roles of nitric oxide Snyder, S. H;Bredt, D. S
  10. Am. J. Surg v.170 Nitric oxide: an overview Rodeberg, D.A., Chaet, M.S., Bass, R.C., Arkovitz, M.S;Garcia, V.E
  11. Hypertension v.20 Chronic inhibition of nitric oxide synthesis, a new model of arterial hypertension Ribeiro, M. O., Antunes, E., De Nucci, G., Lovisolo, S. M;Zats, R
  12. J. Clin. Invest v.90 Determinant of aortic cyclic guanosine monophosphate in hypertension induced by chronic inhibition of nitric oxide synthase Arnal, J. F., Warin, L;Michel, J. B
  13. J. Clin. Invest v.90 A chronic blockade of nitric oxide synthesis in the rat produces systemic hypertension and glomerular damages Baylis, C., Mitruka, B;Deng, A
  14. Hypertension v.21 Angiotensin blockade reverses hypertension during long-term nitric oxide synthase inhibition Pooloc, D. M., Polakowski, J. S., Divish, B. J;Opgenorth, T. J
  15. Proc. Natl. Acad. Sci v.86 Role of endothelium-derived relaxing factor in the regulation of blood pressure Rees, D. D., Palmer, R. M. J;Moncada, S
  16. Am. J. Physiol v.275 Prolonged NOS inhibition in the brain elevates blood pressure in normotensive rats Sakima, A., Teruya, H., yamazato, M., Matayoshi, R., Muratani, H;Fukiyama, K
  17. J. Hypertension v.16 Central and peripheral mechanisms involved in hypertension induced by chronic inhibition of nitric oxide synthase in rats Liu, Y., Tsuchilhashi, T., Kagiyama, S., Matsumura, K., Abe, I;Fujishima, M
  18. Hypertension v.26 L-NAME hypertension alters endothelial smooth muscle function in rat aorta: prevention by trandoprilat and verapamil Kung, C. F., Moreau, P., Takase, H;Luscher, T. E
  19. Am. J. Hypertens v.6 Evidence that the autonomic nervous system plays a major role in the L-NAME-induced hypertension in conscious rats Cunha, R. S., Cabral, A. M;Vasquez, E. C
  20. Hypertension v.26 Sympathetically mediated hypertension caused by chronic inhibition of nitric oxide Sander, M., Hansen, P. G;Victor, R. G
  21. Hypertension v.28 In vitro alteration of vascular reactivity in hypertensiion induced by chronic N-nitro-L-arginine methyl ester Henrion, D., Dowell, E. J., Levy, B. I;Michael, J. B
  22. Eur. J. Pharmacol v.190 Endothelial nitric oxide attenuates vasoconstrictor responses to nerve stimulation and noradrenaline in the rat tail artery Vo, P.A., Reid, J. J;Rand, M. J
  23. J. Hypertens v.11 Persistent hypertension follwing inhibition of nitric oxide formation in the young Wistar rat: role of renin and vascular hypertrophy Morton, J. J., Beattie, E. C., Speirs, A;Gulliver, F
  24. Circ. Res v.72 Inhibition of nitric oxide formation in the nucleus tractus solitarius increases renal sympathetic nerve activity in rabbits Harada, S., Tokunaga, S., Momohara, M., Masaki, H., Tagawa, T., Imaizumi, T;Takeshita, A
  25. J. Hypertens v.5 no.SUP5 Effect of hypertension and its reversal on endothelium dependent relaxations in the rat aorta Luscher, T.F., Raij, L;Vanhoutte, P.M