YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Synthesis of Yakuchinone Derivatives and Their Inhibitory Activities on Nitric Oxide Synthesis

Yakuchinone과 그 유도체의 합성 및 Nitric Oxide생성 저해효능

  • 윤정화 (숙명여자대학교 약학대학) ;
  • 안한나 (숙명여자대학교 약학대학) ;
  • 류재하 (숙명여자대학교 약학대학) ;
  • 김희두 (숙명여자대학교 약학대학)
  • Published : 2001.02.01
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Abstract

Novel yakuchinone derivatives have been designed, synthesized and evaluated their inhibitory activity of NO production in lipopolysaccharide (LPS)-activated macrophages. From this study, some enone compounds have been found to be highly active in the assay. In view of the importance of NO in septic shock and inflammation, these compounds may be useful candidates for the development of new drug to treat endotoxemia and inflammation accompanying overproduction of NO.

Keywords

References

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